JCE Online Journal of Chemical EducationDivision of Chemical Education, American Chemical SocietyAmerican Chemical Society
 | Subscriptions  | Software Orders  | Support  | Contributors  | Advertisers  | 



  Home > JCE Print > Journal of Chemical Education > Issues > 2007  > December  >
Research: Science and Education
Unequal Activities of Enantiomers via Biological Receptors: Examples of Chiral Drug, Pesticide, and Fragrance Molecules
Albrecht Mannschreck and Roland Kiesswetter
Department of Organic Chemistry, University of Regensburg, D-93040 Regensburg, Germany

Erwin von Angerer
Department of Pharmacy, University of Regensburg, D-93040 Regensburg, Germany

Cover
December 2007
Vol. 84 No. 12
p. 2012

Abstract
A molecule coming from outside an organism can form a ligand–receptor complex. Upon its formation, a message is transmitted, for example, to certain cells. In this way, two enantiomers can emit messages that differ, either quantitatively or qualitatively. In the present article, these facts are taken as a common basis for the actions of chiral drug, pesticide, and fragrance molecules. For each of these groups, a few examples of current interest were selected. At present, the demand for single enantiomers in medicine and agriculture is economically highly significant. We propose a two-hour lecture, emphasizing the similarity between the different types of receptor-mediated actions of enantiomers, thus connecting some seemingly unrelated subjects in the university curricula. The lecture is intended for medicinal chemistry students; in addition, it should be suitable for the third-year chemistry students who are interested in the applications presented here.

See JCE Featured Molecules.

Supplement
Aspects of pharmacokinetics as well as the naming and marketing of drug and pesticide enantiomers are described.
*
Download
Contents
More Information
*
Citation
Mannschreck, Albrecht; Kiesswetter, Roland; von Angerer, Erwin. J. Chem. Educ. 2007, 84, 2012.
*
Keywords
Agricultural Chemistry; Analogies / Transfer; Biochemistry; Bioorganic Chemistry; Chirality / Optical Activity; Drugs / Pharmaceuticals; Enantiomers; Medicinal Chemistry; Organic Chemistry; Receptors; Stereochemistry; Textbooks / Reference Books; Upper-Division Undergraduate
*
History
Created:
Last Updated:
10/25/2007
10/31/2007
  Home > JCE Print > Journal of Chemical Education > Issues > 2007  > December  > Page 2012



Chemistry Teacher Connection

The "Chemistry Teacher Connection" (CTC) is especially for high school chemistry teachers. For only $40/year, it offers an online-only subscription to CLIC along with membership in the Division of Chemical Education, normally $65/year. CTC subscribers receive access to all articles and supplements from 1996 through the current issue.


C&EN CLICs

Through special arrangement with the ACS, JCE High School CLIC is now able to provide subscribers with online access to Chemical & Engineering News articles that have been selected specifically for secondary science instructors and their students. 


JCE Collections Available
Occasionally, collections of JCE back issues become available for donation to individual teachers, schools, or libraries. JCE matches collections with interested recipients. Recipients pay shipping costs or pick up the collection.

Contributions Welcome
JCE welcomes your submission

Subscriptions

Fishing for New Ideas
Always in the
process of
improving, CLIC
welcomes ideas and comments.

Email Us

NSF logoDivCHEDACS ACS PubsFor journals in other fields of chemistry visit ACS Publications.