An Exercise on Structure Elucidation Based on a Tricky Aldol Reaction
Manuel González Sierra, Silvina C. Pellegrinet, María I. Colombo, and Edmundo A. Rúveda
Instituto de Química Orgánica y de Síntesis (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, U.N.R. Suipacha 531, Rosario 2000, Argentina
An exercise on structure elucidation for advanced undergraduate students is described. To determine the structure of an unknown product, students are required to use spectra together with an organic chemistry mechanism. This exercise exemplifies the procedure commonly used in research, thus helping students develop problem-solving skills. In addition, it highlights the potential of modern NMR techniques such as one- and two-dimensional NMR.
Supplement
Student handouts: background information, molecular formula, IR spectrum, 1- and 2-D NMR spectra, and step-by-step procedure; Instructor notes: answers to step-by-step procedure and assigned spectra
González Sierra, Manuel; Pellegrinet, Silvina C.; Colombo, María I.; Rúveda, Edmundo A. J. Chem. Educ.2008, 85, 1094.
Keywords
Inquiry-Based / Discovery Learning; IR Spectroscopy; Laboratory Instruction; Mechanisms of Reactions; Natural Products; NMR Spectroscopy; Organic Chemistry; Problem Solving / Decision Making; Upper-Division Undergraduate
History
Created:
Last Updated:
6/23/2008
7/2/2008
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