As an introductory text to this field, this book can be quite informative, covering the most pertinent parts of molecular mechanics. This title covers the basics of molecular mechanics in a readable straightforward manner and it is pertinent to beginners and experienced modelers alike. The novice user will be exposed to the basics of molecular mechanics necessary to perform and interpret such calculations, while advanced users may find approaches to complement and amplify their ongoing studies. The text offers homework problems to help readers identify and understand the more important concepts introduced in the chapter, and the answers are provided in one of the appendices. One slight drawback for the book is that although numerous references are cited, certain sections are not as up to date as they should be. In spite of this, this text is a good primer for use in the early education of molecular modeling students.

The text is divided into 8 chapters. An Overview is followed by Organics; Peptides and Proteins; Drug Design; DNA; Synthetic Polymers; Inorganics; and Force Fields. Each chapter includes numerous informative homework assignments, references, further reading, and supplemental case studies sections denoted in boxes. In each section of a chapter the concept is introduced in a background section, which is followed by meth ods and results sections. The appendices are Stereochemical Terms, Thermodynamic Corrections, Molecular Dynamics, Monte Carlo Sampling, and Answers to Homework.

The Organics chapter is especially well done, showing the pitfalls that may trap the unwary in small-molecule work. The Peptides and Proteins section provides a good ground for work in this particular area and the discussion is deep enough to be of value to all in this field. The Drug Design chapter covers some basic concepts in this subject, but as expected cannot be an all-inclusive treatise on this diverse field. The DNA chapter spans a large amount of the material very well and is necessary to understand current concepts important in this arena of molecular modeling. The Synthetic Polymers section tries to address the basic issues, but does not come as close as some of the other chapters to offering the rudiments of this field. The Inorganics chapter elucidates most of the important details required to begin serious molecular modeling experiments, but is limited because of the shortcomings of molecular mechanics itself. The Force Fields section is too brief to be of value to an expert, but it provides a nice review and perspective for the beginner to think about parameterization problems and their limitations. Overall, the text provides a relatively solid and effective introduction to the field of molecular mechanics and would be a useful addition to any faculty, student, or institutional library-especially in light of recent advancements in the desktop molecular modeling field, where virtually anyone can gain insight into almost any chemical system.