In 1833, William Beaumont published his Experiments and Observations on the Gastric Juice and the Physiology of Digestion. He had tracked, cajoled, forced, and studied his reluctant patient, Alexis St. Martin, whose gastric fistula was Beaumont's window into the wonders of digestion, until he had formed the modern study of digestive processes and created the great tradition of the physician investigator.
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